Functional genomics and systems biology have opened doors to previously inaccessible genomic information and holistic approaches to study complex networks of genes and proteins in the central nervous system. Nonetheless, our current understanding of these complex gene regulatory mechanisms has yet lacked sufficient mechanistic resolution for further translational breakthroughs. We aim to better understand neuroepitranscriptomics (RNA regulation through dynamic chemical modifications) underlying cognitive development and decline using animal model systems.
*Epitranscriptomics: a burgeoning field to investigate the chemical and structural properties, physiological functions, and disease relevance of chemical RNA modifications. The new field is rapidly evolving and integrating with life sciences from cancer and stem cell biology, vaccine development, to neuroscience.